• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to a cosmetic preparation containing a UV filter combination from a) hexyl-2- [4- (diethylamino) -2-hydroxybenzoyl] benzoate (inci: diethylamino hydroxybenzoyl hexyl benzoate), b) 4- (tert-butyl) -4'-methoxydibenzoylmethane (inc: butyl methoxydibenzoylmethane) c) polyglyceryl fatty acid ester, the preparation being free of 3- (4-methylbenzyliden) camphor, 2-hydroxy-4-methoxybenzenophenone (incyl (oxybenzone), 4-methoxycinnamic acid (2-ethylhexyl ester), 4-methoxy-cinnamic acid isoamyl ester and ethylhexyl-2-cyano-3,3-diphenylacrylate inci-octocrylene), process for reducing Textile stain caused by cosmetic preparations containing sunscreen filter uv, characterized in that the cosmetic contains polyglyceryl fatty acid ester as emulsifier and use of polyglyceryl fatty acid ester in cosmetic preparations containing sunscreen filter uv to facilitate the washing ability. UV sunscreen filters of textiles contaminated with the preparations.
    公开号:BR102018000894A2
    申请号:R102018000894
    申请日:2018-01-16
    公开日:2018-10-30
    发明作者:Borchers Kathrin；Schuldt Lisa；Sprock Sarah；Von Der Fecht Stephanie；Schade Tatjana
    申请人:Beiersdorf Ag；
    IPC主号:
    专利说明:

    (54) Title: OCTOCRYLENE-FREE SUNSCREEN WITH POLYGLYCERYL-10ESTEARATE (51) Int. Cl .: A61K 8/37; A61K 8/35; A61K 8/39; A61K 8/41; A61K 8/49; (...) (30) Unionist Priority: 18/01/2017 DE 102017200723.0 (73) Holder (s): BEIERSDORF AG (72) Inventor (s): TATJANA SCHADE; KATHRIN BORCHERS; STEPHANIE VON DER FECHT; LISA SCHULDT; SARAH SPROCK (85) National Phase Start Date:
    16/01/2018 (57) Abstract: The invention relates to a cosmetic preparation containing a combination of UV filter, from a) hexyl-2- [4- (diethylamino) -2-hydroxybenzoyl] benzoate (INCI: diethylamino hydroxybenzoyl hexyl benzoate), b) 4- (tert.-butyl) -4 -methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane) c) polyglyceryl fatty acid ester, the preparation being free of 3- (4-methylbenzyliden)-camphor , 2-hydroxy-4methoxybenzenophenone (INCI: oxybenzone), ester (4-methoxycinnamic acid 2-ethylhexyl, 4-methoxy-cinnamic acid isoamyl ester and ethylhexyl-2-cyano-3,3-diphenylacrylate INCI: octocrylene) , process for the reduction of textile stain caused by cosmetic preparations containing UV sun protection filter, characterized by the fact that the cosmetic contains polyglyceryl fatty acid ester as an emulsifier and use of polyglyceryl fatty acid ester in cosmetic preparations containing UV sun protection filter for facilitate the washing capacity of prot filters UV solar removal of textiles contaminated with preparations.
    1/22 “OCTOCRYLENE-FREE SUNSCREEN WITH POLYGLYCERYL10-STEARATE” [0001] The present invention relates to a cosmetic preparation containing a combination of UV filter, from
    a) hexyl-2- [4- (diethylamino) -2-hydroxybenzoyl] benzoate (INCI: diethylamino hydroxybenzoyl hexyl benzoate),
    b) 4- (tert-butyl) -4'-methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane)
    c) polyglyceryl fatty acid ester, the preparation being free of 3- (4-methylbenzyliden) -phlorphorus, 2-hydroxy-4-methoxybenzenophenone (INCI: oxybenzone), ester (4-methoxycinnamic acid 2-ethylhexyl, isoamyl acid ester
    4-methoxy-cinnamic and ethylhexyl-2-cyano-3,3-diphenylacrylate INCI: octocrylene), a process for reducing the textile stain caused by cosmetic preparations containing a UV sunscreen filter, characterized by the fact that the cosmetic contains polyglyceryl fatty acid ester as an emulsifier and use of polyglyceryl fatty acid ester in cosmetic preparations containing UV sunscreen filters to facilitate the washing capacity of UV sunscreen filters of textiles contaminated with the preparations.
    [0002] The trend away from elegant pallor to “healthy sporty brown skin” has remained unshakable for years. To achieve the same, people expose their skin to solar radiation, since it causes a pigment formation in the sense of forming melanin. Ultraviolet radiation from sunlight, however, also has a harmful effect on the skin. In addition to acute damage (heat stroke), long-term damage occurs, such as
    Petition 870180072198, of 17/08/2018, p. 5/31
    2/22 as a high risk of getting sick from skin cancer due to excessive irradiation with UVB band light (wavelength: 280 to 320 nm). The excessive action of UVB and UVA radiation (wavelength: 320 to 400 nm) also leads to a weakening of the elastic and collagen fibers in the connective tissue. This leads to numerous phototoxic and photoallergic reactions and, as a consequence, premature skin aging.
    [0003] Therefore, to protect the skin, a series of sun protection filter substances have been developed, which can be used in cosmetic preparations. These UVA and UVB filters are grouped in most industrialized countries in the form of positive lists, such as in Annex 7 to the regulation on cosmetics.
    [0004] The large number of commercially available sunscreens, however, should not be misleading as to the fact that these state of the art preparations have a number of disadvantages.
    [0005] Cosmetic sunscreens have the problem that a large number of UV filters are not particularly well soluble in preparations. In particular, when preparations are developed with a high sun protection factor and high UV filter content, the solubility of 4- (terc.butil) -4'-methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane) and triazine derivatives represents a problem for the developers. To solve this problem, in the past, the octocrylene liquid UV-B filter was used as a UV filter and solvent. Octocylene serves, in addition to
    Petition 870180072198, of 17/08/2018, p. 6/31
    3/22 of this, for the photostabilization of 4- (terc.-butyl) -4'metoxidibenzoylmethane.
    [0006] The disadvantage of the state of the art now consists in the fact that the use of octocrylene, despite approval by regulatory authorities, is not entirely contestable and in the evaluations of some consumer magazines (for example, ecological testing) lead devaluations in the product class. This negative assessment is therefore motivated by the fact that some scientists suspect that this UV filter could possibly have hormonal effects. Also if, despite the worldwide use of this UV filter for decades in sunscreens, no negative effects on humans are known, consumers have the desire to avoid preparations with such constituent substances.
    [0007] Therefore, the objective of the present invention was to remove the disadvantages of the state of the art and to develop a sunscreen with a high sun protection factor, in which the UV filters (in particular 4- (terc.-butyl) 4 ' -methoxydibenzoylmethane and triazine derivatives, in particular 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} 6- (4-methoxyphenyl) -1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) and 2,4,6-tris- [anilino- (pcarbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: ethyl hexyl triazone) ) are dissolved in a stable way, without using octocrylene as a solvent and stabilizer.
    [0008] Cosmetic preparations, such as sun protection preparations, which are applied to the skin, regularly come into contact (intentionally or unintentionally)
    Petition 870180072198, of 17/08/2018, p. 7/31
    4/22 intentional) with clothing and pieces of clothing (for example, towels), in which the preparations adhere, in part (for example, as friction or because these are absorbed by the fibrous material). Thus, depending on the type of constituent substances, stains and discolorations result, in particular, in light textiles. These discolorations are caused, in particular, by non-water-soluble UVA and broadband filters, such as 4- (terc.-butyl) -4'metoxidibenzoylmethane (INCI: butyl methoxydibenzoylmethane), hexyl acid ester (2 - [- 4- (diethylamino) -2hydroxybenzoyl] benzoic (INCI: diethylamino hydroxybenzoyl hexyl benzoate) and 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1 , 3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) Stains are difficult to remove through washing with conventional detergents and even increase during the washing process through interactions with washing water ions.
    [0009] Therefore, the aim of the present invention was to remove the disadvantages of the prior art and to develop a cosmetic preparation (in particular, a sunscreen), which contains non-water-soluble UV-A filters, such as 4- (tert .-butyl) -4'-methoxydibenzoylmethane (INCI:
    butyl methoxydibenzoylmethane) and hexyl ester (2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid (INCI: diethylamino hydroxybenzoyl hexyl benzoate), as well as optionally broadband filters such as bis-ethylhexyloxyphenol methoxyphenyl triazine, that very simply can be
    Petition 870180072198, of 17/08/2018, p. 8/31
    5/22 washed by textiles contaminated with the preparation.
    [0010] The objectives are surprisingly solved through a cosmetic preparation containing a combination of UV filter from
    a) hexyl-2- [4- (diethylamino) -2-hydroxybenzoyl] benzoate (INCI: diethylamino hydroxybenzoyl hexyl benzoate),
    b) 4- (tert-butyl) -4'-methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane)
    c) polyglyceryl fatty acid ester, the preparation being free of 3- (4-methylbenzyliden) -phlorphorus, 2-hydroxy-4-methoxybenzenophenone (INCI: oxybenzone), ester (4-methoxycinnamic acid 2-ethylhexyl, isoamyl acid ester
    4-methoxy-cinnamic and ethylhexyl-2-cyano-3,3-diphenylacrylate
    INCI: octocrylene).
    [0011] The objectives are surprisingly solved, moreover, through a process to increase the washing capacity of organic UV-A filters, soluble in oil and / or organic broadband filters, soluble in textile oil, that are contaminated with a cosmetic preparation, which contains these UV-A filters and / or broadband filters, characterized by the fact that the cosmetic preparation is added polyglyceryl fatty acid ester, as well as by a process to reduce the textile stain caused by cosmetic preparations containing UV sun protection filters, characterized by the fact that the cosmetic contains polyglyceryl fatty acid ester as an emulsifier.
    Petition 870180072198, of 17/08/2018, p. 9/31
    6/22 [0012] Not last, the objectives are solved by the use of polyglyceryl fatty acid ester in cosmetic preparations containing UV sun protection filters, to facilitate the washing capacity of the UV sun protection filters of textiles contaminated with the preparations.
    [0013] In fact, the state of the art knows the documents
    DE 102014216602, DE 102014202956, DE 102013213170, DE
    102013200819, as well as DE 102011088962, however, these reports could not point the way to the present invention.
    [0014] In the context of this publication, the formulations "according to the invention", "preparation according to the invention" and so on, always refer to preparations according to the invention, processes and uses, that is , also to the preparations, in which the uses according to the invention are carried out, as well as to the preparations, with which the process according to the invention is carried out.
    The particularly preferred polyglyceryl fatty acid ester according to the invention is, in this case, polyglyceryl-10 stearate (INCI: polyglyceryl-10 stearate). [0016] According to the invention it is advantageous, if the preparation contains 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1, 3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) and / or 2,4,6-tris- [anilino (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5- triazine (INCI: ethyl hexyl triazone).
    [0017] In this case, it is preferable, according to the invention, if the preparation contains a combination of the preparation 2,4-bisPetition 870180072198, of 08/17/2018, p. 10/31
    7/22 {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) 1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) and 2 , 4,6-tris- [anilino- (p-carbo-2'-ethyl-1'hexyloxy)] - 1,3,5-triazine (INCI: ethyl hexyl triazone).
    [0018] The advantageous embodiments of the present invention according to the invention, are characterized by the fact that the preparation contains salts of 2-phenylbenzimidazole-5-sulfonic acid and / or 2-ethylhexyl-2hydroxybenzoate (INCI: ethyl hexyl salicylate ).
    [0019] Preferred embodiments of the present invention according to the invention, are characterized by the fact that the preparation contains salts of 2-phenylbenzimidazole-5-sulfonic acid and / or 2-ethylhexyl-2hydroxybenzoate (INCI: ethylhexyl salicylate ).
    [0020] In the sense of the present invention, it is advantageous if the preparation contains hexyl 2- [4- (diethylamino) -2hydroxybenzoyl] benzoate (INCI: diethylamino hydroxybenzoylhexyl-benzoate) in a concentration of 0.05 to 1.5% by weight , based on the total weight of the preparation.
    [0021] In the sense of the present invention it is preferable, if the preparation contains hexyl 2- [4- (diethylamino) -2hydroxybenzoyl] benzoate (INCI: diethylamino hydroxybenzoylhexyl-benzoate) in a concentration of 0.05 to 1.0% by weight , based on the total weight of the preparation.
    [0022] According to the invention it is advantageous, if the preparation contains 4- (terc.-butyl) -4'-methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane) in a concentration of 1.00 to 5.00% by weight, with based on the total weight of the preparation.
    Petition 870180072198, of 17/08/2018, p. 11/31
    8/22 [0023] According to the invention it is preferable, if the preparation contains 4- (terc.-butyl) -4'-methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane) in a concentration of
    1.25 to 4.75% by weight, based on the total weight of the preparation. [0024] To obtain particularly advantageous results according to the invention, with respect to the washing capacity of the preparation according to the invention from textiles, the weight ratio of diethylamino hydroxybenzoyl hexyl benzoate to butyl methoxydibenzoylmethane should be 0.2 : 1 to
    1: 5.
    [0025] Advantageous embodiments of the present invention according to the invention, are characterized by the fact that the preparation contains polyglyceryl-10 stearate (INCI polyglyceryl-10 stearate) in a concentration of 0.05 to 1.25% by weight , based on the total weight of the preparation.
    [0026] Preferred embodiments of the present invention according to the invention, are characterized by the fact that the preparation contains polyglyceryl-10 stearate (INCI polyglyceryl-10 stearate) in a concentration of 0.5 to 1.00% by weight , based on the total weight of the preparation.
    [0027] In the sense of the present invention it is advantageous, if the total concentration of 2,4-bis - {[4- (2-ethylhexyloxy) -2hydroxy] -phenyl} -6- (4-methoxyphenyl) -1, 3,5-triazine (INCI: bisetylhexyloxyphenol methoxyphenyl triazine) and 2,4,6-tris [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine ( INCI: ethyl hexyl triazone) in the preparation amounts to 0.1 to 4.5% by weight, based on the total weight of the preparation.
    Petition 870180072198, of 17/08/2018, p. 12/31
    9/22 [0028] In this case, three configurations of the case can be distinguished according to the invention:
    whether the preparation according to the invention contains 2,4-bis {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) 1,3,5-triazine (INCI : bis-ethylhexyloxyphenol methoxyphenyl triazine) and none 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'hexyloxy)] - 1,3,5-triazine (INCI: ethyl hexyl triazone), then bis-ethylhexyloxyphenol methoxyphenyl triazine is advantageously used according to the invention, in the preparation in a concentration of 0.05 to 4.00% by weight, based on the total weight of the preparation.
    [0029] If the preparation according to the invention does not contain any 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6 (4-methoxyphenyl) -1,3 , 5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine), but contains 2,4,6-tris- [anilino- (pcarbo-2'-ethyl-1'-hexyloxy)] - 1,3,5- triazine (INCI: ethyl hexyl triazone), then ethyl hexyl triazone is advantageously used according to the invention, in the preparation, in a concentration of 0.1 to 4.5% by weight, based on the total weight of the preparation. [0030] If the preparation according to the invention contains both 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4methoxyphenyl) -1,3,5 -triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) as well as 2,4,6-tris- [anilino- (pcarbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI : ethyl hexyl triazone), then bis-ethylhexyloxy phenol methoxyphenyl triazine is advantageously used, according to the invention, in the preparation in a concentration of 0.05 to 4.00% by weight and ethylhexyl triazone is used in preparation in a concentration
    Petition 870180072198, of 17/08/2018, p. 13/31
    10/22 from 0.1 to 4.5% by weight, in each case based on the total weight of the preparation. This combination is particularly preferred according to the invention.
    [0031] Advantageous embodiments of the present invention according to the invention, are characterized by the fact that the total concentration of 2-phenylbenzimidazole-5-sulfonic acid and 2-ethylhexyl-2hydroxybenzoate salts (INCI: ethylhexyl salicylate ) in the preparation is 0.05 to 5.00% by weight, based on the total weight of the preparation.
    [0032] In this case, three configurations of the case according to the invention can be distinguished:
    [0033] if the preparation according to the invention contains salts of 2-phenylbenzimidazole-5-sulfonic acid and no 2ethylhexyl-2-hydroxybenzoate (INCI: ethylhexyl salicylate), then it is advantageous according to the invention, use this compound in a concentration of 0.1 to 1.5% by weight, based on the total weight of the preparation.
    [0034] If the preparation according to the invention does not contain any salts of 2-phenylbenzimidazole-5-sulfonic acid, for this, however, 2-ethylhexyl-2-hydroxybenzoate (INCI: ethylhexyl salicylate), then it is advantageous, according to the invention, use this compound in a concentration of 0.05 to 5.00% by weight, based on the total weight of the preparation.
    [0035] If the preparation according to the invention contains both salts of 2-phenylbenzimidazole-5-sulfonic acid as well as 2-ethylhexyl-2-hydroxybenzoate (INCI: ethylhexyl salicylate), then it is advantageous, according to the invention,
    Petition 870180072198, of 17/08/2018, p. 14/31
    11/22 use the 2-phenylbenzimidazole-5-sulfonic acid salts in a concentration of 0.1 to 3.00% by weight, based on the total weight of the preparation and the 2-ethylhexyl-2-hydroxybenzoate (INCI : ethyl hexyl salicylate) sulfonic acid salts in a concentration of 0.05 to 5.00% by weight, based on the total weight of the preparation. This combination is particularly preferred according to the invention.
    [0036] This results in a combination being very particularly preferred according to the invention, from
    a) hexyl-2- [4- (diethylamino) -2-hydroxybenzoyl] benzoate (INCI:
    diethylamino hydroxybenzoyl hexyl benzoate),
    b) 4- (tert-butyl) -4'-methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane),
    c) polyglyceryl-10 stearate (INCI: polyglyceryl-10 stearate),
    d) 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4methoxyphenyl) -1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine),
    e) 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5triazine (INCI: ethyl hexyl triazone),
    f) salts of 2-phenylbenzimidazole-5-sulfonic acid and
    g) 2-ethylhexyl-2-hydroxybenzoate (INCI: ethylhexyl salicylate), the preparation being free of 3- (4-methylbenzyliden) camphor, 2-hydroxy-4-methoxybenzophenone (INCI: oxybenzon), ester (2-ethylhexyl) of 4-methoxycinnamic acid, 4-methoxycinnamic isoamyl ester and ethylhexyl-2-cyano-3,3 Petition 870180072198, of 08/17/2018, p. 15/31
    12/22 diphenylacrylate (INCI: octocrylene).
    [0037] In this case, the concentrations indicated above are preferably used.
    [0038] Furthermore, it is advantageous, according to the invention, if the preparation contains a combination of phenoxyethanol and tocopheryl acetate, respectively, tocopherol.
    [0039] In this case, preferably according to the invention, the combination of phenoxyethanol and tocopheryl acetate is used.
    [0040] In such a case, it is again advantageous, according to the invention, if the preparation contains from 0.1 to 0.9% by weight, of phenoxyethanol and from 0.05 to 0.5% by weight, of tocopheryl acetate, in each case based on the total weight of the preparation.
    [0041] Advantageous embodiments of the present invention according to the invention, are characterized by the fact that the preparation contains one or more of the perfumes of hexyl salicylate, linayl acetate, 2-isobutyl-4hydroxy-4-methyltetrahydropyran, diester of adipic acid, methyl-heptenone, alpha-isomethionone, butylphenylmethylpropioal, coumarin, hexylcinnamal, limonene, linalool, diethyl succinate, hydroxy-isohexyl-3cyclohexenecarboxaldehyde, diethyl succinate, menthyl PCA and benzyl methylene benzone, benzyl, benzylate, citronate , benzyl cinnamate, benzyl salicylate, citronellol, eugenol, geraniol.
    [0042] Advantageous embodiments according to the invention, are further characterized by the fact that the
    Petition 870180072198, of 17/08/2018, p. 16/31
    13/22 preparation contains ethylhexylglycerin, propylene glycol, butylene glycol, 2-methylpropan-1,3-diol, 1,2-pentanediol, 1,2hexanediol, 1,2-octanediol and / or 1,2-decanediol.
    [0043] Not last, it is advantageous, according to the invention, if the preparation does not contain any parabens, as well as any methylisothiazolinone, chloromethylisothiazolinone and DMDM-hydantoin, therefore, it is free of these constituent substances.
    [0044] The preparation according to the invention generally represents an oil-in-water emulsion (O / W emulsion). It may contain the usual constituent substances for such preparations.
    [0045] The preparation according to the invention can advantageously contain wetting agents. As moisturizers, substances or mixtures of substances are designated, which give cosmetic preparations the property, after application or distribution on the skin surface, of reducing the release of moisture from the corneal layer (also referred to as transepidermal water loss (TEWL) ) and / or positively influence the hydration of the corneal layer.
    [0046] Useful moisturizers in the sense of the present invention are, for example, glycerin, lactic acid and / or lactates, in particular, sodium lactate, butylene glycol, propylene glycol, Gum-1 disaccharides, wild soy, ethylhexyloxyglycerine, pyrrolidinecarboxylic acid and urea. In addition, it is advantageous, in particular, to use polymeric humectants from the group of water-soluble and / or water-swellable polysaccharides and / or
    Petition 870180072198, of 17/08/2018, p. 17/31
    14/22 gellifiable with the aid of water. In particular, hyaluronic acid, chitosan and / or a fucose-rich polysaccharide, which is deposited in Chemical Abstracts under registration number 178463-23-5 and can be obtained, for example, by the name Fucogel, are advantageous. ® 1000 from SOLABIA SA The humectants can also be used, advantageously, as active anti-wrinkle substances to protect against skin changes, such as occur, for example, in skin aging.
    [0047] The cosmetic preparations according to the invention may furthermore advantageously, although not necessarily, contain fillers, which continue to improve, for example, the sensory and cosmetic properties of the formulations and cause or increase, for example, a velvety or silky feeling of the skin. Advantageous fillers in the sense of the present invention are starch and starch derivatives (such as, for example, tapioca starch, starch diphosphate, aluminum or sodium starch octenyl succinate and the like), pigments, which have no effect whatsoever UV filter or coloring effect (such as, for example, boron nitride and so on) and / or Aerosile® (CAS-Nr. 7631-86-9) and / or talc and / or polyethylene, nylon, dimethylsilylate silica.
    [0048] According to the invention it is preferable, if the preparation according to the invention contains silica dimethylsilylate.
    [0049] Advantageous embodiments of the present invention according to the invention, are characterized by the fact that
    Petition 870180072198, of 17/08/2018, p. 18/31
    15/22 the preparation contains one or more oils selected from the group of the compounds butyleneglycol tipprilate / tipprate, phenethyl benzoate, C12-15 alkyl benzoate, dibutyl adipate, diisopropyl sebacate, tipprilyl carbonate, tartrates di-C12-13 alkyl, butyloctyl salicylate, diethylhexyl syringylidene malonate, hydrogenated castor oil dimerate, triheptanoin, C1213 alkyl lactate, C16-17 alkyl benzoate, propylheptyl caprylate, caprylic / capric triglyceride, 2, 6-diethylhexyl naphthalate, octyldodecanol, caprylic / capric triglyceride, ethylhexyl cocoate.
    In this case, according to the invention it is preferable, if the preparation contains dibutyl adipate, tipprilyl carbonate and / or C12-C15 alkyl benzoate.
    [0051] The aqueous phase of the preparations according to the invention can advantageously contain usual cosmetic adjuvants, such as, for example, alcohols, in particular those with low carbon number, preferably ethanol and / or isopropanol or polyols with low number of carbon, as well as its ethers, preferably propylene glycol, glycerin, electrolytes, self-tanners, as well as, in particular, one or more thickeners, which or which can be advantageously selected from the group of silicon dioxide, aluminum silicates, polysaccharides or its derivatives, for example, hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopols, for example,
    Petition 870180072198, of 17/08/2018, p. 19/31
    16/22 carbopols of types 980, 981, 1382, 2984, 5984, in each case individually or in combination. Other advantageous thickeners according to the invention are those with the name INCI acrylate / C10-30 alkyl crospolymer (for example, Pemulen TR 1, Pemulen TR 2, Carbopol 1328 from NOVEON), as well as Aristoflex AVC (INCI: copolymer of ammonium acryloyldimethyltaurate / VP).
    [0052] In this case, it is preferable, according to the invention, if the preparation contains xanthan gum, acrylate polymer / C10-C30 cross-linked alkyl acrylate and / or vinylpyrrolidone / hexadecene copolymer.
    [0053] A glycerin content of at least 5% by weight, based on the total weight of the preparation, is particularly advantageous according to the invention.
    [0054] Furthermore, it is of particular advantage, according to the invention, if the preparation according to the invention contains ethanol.
    [0055] Advantageous embodiments of the present invention according to the invention, are characterized by the fact that the preparation contains one or more compounds selected from the group of compounds alpha lipoic acid, folic acid, phytene, D-biotin, coenzyme Q10 , alpha-glycosylrutin, carnitine, carnosine, natural and / or synthetic isoflavonoids, flavonoids, creatine, creatinine, taurine, β-alanine, panthenol, magnolol, honokiol, tocopheryl acetate, dihydroxyacetone; 8-hexadecen-1,16dicarboxylic acid, glyceryl glucose (2-hydroxyethyl) urea, hyaluronic acid and / or its salts and / or licochalcona A.
    Petition 870180072198, of 17/08/2018, p. 20/31
    [0056] According to the invention, the preparation according to the invention advantageously contains film-forming agents. The film former in the sense of the present invention are substances of different composition, which are characterized by the following properties: dissolving a film former in water or other suitable solvents and then applying the solution to the skin, then, after evaporation of the solvent, it forms a film, which essentially serves to fix the sunscreens on the skin and thus increase the product's resistance to water.
    [0057] It is advantageous, in particular, to select film formers from the group of polymers based on polyvinylpyrrolidone (PVP) • ch-ch 2 - [0058] Particularly preferred are the copolymers of polyvinylpyrrolidone, for example, the copolymer of hexadecene PVP and the eicosene copolymer PVP, which can be obtained under the trade names Antaron V216 and Antaron V220 from GAF Chemicals Corporation.
    [0059] Likewise, other polymeric film-forming agents, such as, for example, sodium polystyrenesulfonate, which can be obtained under the trade name Flexan 130 from National Starch and Chemical Corp., are advantageous. and / or polyisobutene, which can be obtained from Rewo under the trade name PIB 1000. Other polymers
    Petition 870180072198, of 17/08/2018, p. 21/31
    Suitable 18/22 are, for example, polyacrylamides (Seppigel 305), polyvinyl alcohols, PVP, PVP / VA copolymers, polyglycols, acrylate / octylacrylamide copolymers (Dermacryl 79). Likewise, it is advantageous to use dimeric dilinoleate hydrogenated castor oil (CAS 646054-62-8, INCI dilinoleate hydrogenated castor oil dimer), which can be purchased from Kokyu Alcohol Kogyo by the name Risocast DA-H or, then also PPG-3 benzyl ether myristate (CAS 403517-45-3), which can be purchased under the trade name Crodamol STS from Croda Chemicals.
    [0060] According to the invention, the use of the preparation according to the invention is for protection against skin aging (in particular, for protection against skin aging by UV), as well as sunscreen.
    Comparative test (wash test) and example [0061] With the following test, the effect according to the invention could be proved by way of example. Various emulsifying systems have been produced. Also a system, which contains 0.8% of the polyglyceryl-10 stearate adjuvant according to the invention, in order to determine the stain reduction effect (b * reduction) compared to a formulation without adjuvant according to the invention by using the method described.
    [0062] As proof of the better washing capacity and less formation of stains in the preparations according to the invention, in vitro research was carried out, the results of which are shown in table 1.
    Petition 870180072198, of 17/08/2018, p. 22/31
    19/22 [0063] Several emulsions of sunscreens have been researched with respect to the formation of yellow spots through an in vitro application / wash cycle. In this case, pre-washed white cotton monitors (100% cotton) are used. To that end, 25 mg each of the test formulation is distributed evenly on Schonberg's PMMA plates (5.0 x 5.0 cm) and transferred directly to the test textile by means of contact pressure. Then, the stained cotton samples are air dried for 12 hours in laboratory conditions.
    [0064] After drying, a colorimetric characterization of the resulting initial stain was performed, by measuring the degree of yellow color with the spectrocolor colorimeter (Dr. Lange), Farbmess-Software: spectral-QC, measurement geometry version: d / 8th, excluded brightness component, type of light: D65 (corresponds to medium morning light), calibration standard: LZM 268, measurement aperture: 10 mm, sample bottom: base paper without optical clarifier, test climate: 21oC (+ 1oC), 41% (+4%) relative humidity.
    [0065] For the evaluation, the change in the b value of the CIE-Lab color measurement system was applied. The B axis in the CIE-Lab system is characterized by yellow / blue printing, with positive b values representing an increase in the proportion of yellow color. The higher the b value, the greater the yellow impression.
    [0066] After the measurement process, a separate wash of the test cloths was performed on the Linitest Plus (Atlas) color and wash resistance equipment (60 oC, 1
    Petition 870180072198, of 17/08/2018, p. 23/31
    20/22 hours, 20 rpm, Ariel Compact powder detergent, 10 metal spheres as an additional charge) and then a rinsing process (20 oC, 15 minutes, tap water).
    [0067] After drying for 12 hours in laboratory conditions, a colorimetric characterization of the resulting stain was again performed, by measuring the color values, as already described, with the spectro-color colorimeter (Dr. Lange).
    [0068] The CIE-Lab system or L * a * b * color space is a three-dimensional measurement space, in which all perceptible colors are contained. The color space is constructed based on the opposing color theory. One of the most important properties of the L * a * b * color model is its equipment independence, that is, the colors are defined regardless of the type of their production and reproduction technology.
    [0069] The corresponding EU directive is DIN EN ISO
    11664-4 "Farbmetrik - Teil 4: CIE 1976 L * a * b * Farbenraum". The coordinates of the CIELAB plane are formed from the red / green value a and yellow / blue value b. The brightness axis L is positioned perpendicular to that plane. According to DIN 6174, L, a and b must be written with *, to differentiate themselves from others, for example, the Hunter-Lab system.
    [0070] The following example (recipe 4) should illustrate the present invention, without restricting it. All quantitative data, proportions and percentages are, unless otherwise stated, relative to the weight and the total quantity or the total weight of the preparations.
    Petition 870180072198, of 17/08/2018, p. 24/31
    21/22
    Table 1: Tested formulations and their values in yellow, db value
    Examples [%] INCI 1 2 3 4 sodium stearoyl glutamate 0.30 glyceryl stearate SE 1.00 sodium cetearyl sulfate 0.15 glyceryl stearate citrate 2.00 polyglyceryl-10stearate 0.80 glyceryl stearate 1.00 isopropyl palmitate 6.00 6.00 6.00 6.00 hydrogenated coconut glyceride 1.00 1.00 1.00 1.00 C18-38 alkyl stearatehydroxystearoyl 1.00 0.50 Dicaprilat / Butylene Glycol Dicaprato 2.00 3.00 2.00 2.00 C12-15 alkyl benzoate 5.00 5.00 5.00 5.00 silica dimethyl silylate 1.00 1.00 1.00 1.00 VP / hexadecene copolymer 0.50 0.50 0.50 0.50 glycerin 0.90 8.60 8.60 0.90 cetearyl alcohol 2.00 1.50 1.00 0.50 xanthan gum 0.40 0.40 0.40 0.40 acrylate / C10-30 alkyl acrylate crospolymer 0.10 0.10 0.10 0.10 denatured alcohol 5.00 4.00 4.00 5.00 water + trisodium EDTA 1.00 1.00 1.00 1.00 butylmethoxydibenzoylmethane 3.00 3.00 3.00 3.00 phenylbenzimidazole sulfonic acid 0.50 0.50 0.50 0.50 ethylhexyl salicylate 2.38 2.38 2.38 2.38 ethylhexyl triazone 1.50 1.50 1.50 1.50 bis-ethylhexyloxyphenol methoxyphenyl triazine 2.00 2.00 2.00 2.00
    Petition 870180072198, of 17/08/2018, p. 25/31
    22/22
    diethylamino hydroxybenzoyl hexyl benzoate 0.50 0.50 0.50 0.50 titanium dioxide (nano) 3.00 3.00 3.00 3.00 sodium hydroxide ad pH 7 ad pH 7 ad pH 7 ad pH 7 preservative ad 100 ad 100 ad 100 ad 100 Water ad 100 ad 100 ad 100 ad 100 final values db 6.19 6.09 5.92 3.29
    Petition 870180072198, of 17/08/2018, p. 26/31
    1/4
    权利要求:
    Claims (17)
    [1]
    "CLAIMS"
    1. Cosmetic preparation characterized by the fact that it contains a combination of UV filters from
    a) hexyl-2- [4- (diethylamino) -2-hydroxybenzoyl] benzoate (INCI: diethylamino hydroxybenzoyl hexyl benzoate),
    b) 4- (tert-butyl) -4'-methoxydibenzoylmethane (INCI: butyl methoxydibenzoylmethane)
    c) polyglyceryl fatty acid ester, the preparation being free of 3- (4-methylbenzyliden) -phlorphorus, 2-hydroxy-4-methoxybenzenophenone (INCI: oxybenzone), ester (4-methoxycinnamic acid 2-ethylhexyl, isoamyl acid ester 4-methoxy-cinnamic and ethylhexyl-2-cyano-3,3-diphenylacrylate
    INCI: octocrylene).
    [2]
    2. Process for increasing the washing capacity of organic, oil-soluble UV-A filters and / or organic broadband filters, soluble in textile oil, which are contaminated with a cosmetic preparation, which contains these UV-A filters and / or broadband filters, characterized by the fact that polyglyceryl fatty acid ester is added to the cosmetic preparation.
    [3]
    3. Process to reduce the textile stain caused by the cosmetic preparations containing the UV sun protection filters, characterized by the fact that the cosmetic contains polyglyceryl fatty acid ester as an emulsifier.
    [4]
    4. Use of polyglyceryl fatty acid ester in cosmetic preparations containing UV sun protection filters, characterized by the fact that this is to facilitate the
    Petition 870180072198, of 17/08/2018, p. 27/31
    2/4 washing capacity of the sun protection filters of textiles contaminated with the preparations.
    [5]
    5. Cosmetic preparation according to claim 1, process according to claim 2 or 3 or use according to claim 4, characterized in that the polyglyceryl fatty acid ester is used polyglyceryl10 stearate (INCI: polyglyceryl-10 stearate).
    [6]
    6. Preparation, process or use according to one of the preceding claims, characterized in that the preparation contains 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) and 2,4,6-tris- [anilino- (pcarbo-2'-ethyl-1'-hexyloxy)] - 1 , 3,5-triazine (INCI: ethyl hexyl triazone).
    [7]
    7. Preparation, process or use according to one of the preceding claims, characterized in that the preparation contains salts of 2-phenylbenzimidazole-5sulfonic acid and / or 2-ethylhexyl-2-hydroxybenzoate (INCI: ethyl hexyl salicylate) .
    [8]
    8. Preparation, process or use according to one of the preceding claims, characterized by the fact that the preparation contains hexyl-2- [4- (diethylamino) -2hydroxybenzoyl] (INCI: diethylamino hydroxybenzoyl hexyl benzoate) in a concentration of 0.05 to 1.5% by weight, based on the total weight of the preparation.
    [9]
    9. Preparation, process or use according to one of the preceding claims, characterized in that the preparation contains 4- (terc.-butyl) -4'-methoxydibenzoylmethane
    Petition 870180072198, of 17/08/2018, p. 28/31
    3/4 (INCI: butyl methoxydibenzoylmethane) in a concentration of
    1.00 to 5.00% by weight, based on the total weight of the preparation.
    [10]
    10. Preparation, process or use according to one of the preceding claims, characterized in that the weight ratio of diethylamino hydroxybenzoyl hexyl benzoate to butyl methoxydibenzoylmethane is 0.2: 1 to 1: 5.
    [11]
    11. Preparation, process or use according to one of the preceding claims, characterized in that the preparation contains polyglyceryl-10 stearate (INCI: polyglyceryl-10 stearate) in a concentration of 0.05 to 1.25% by weight, based on the total weight of the preparation.
    [12]
    12. Preparation, process or use according to one of the preceding claims, characterized by the fact that the total concentration of 2,4-bis - {[4- (2-ethylhexyloxy) -2hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: bisetylhexyloxyphenol methoxyphenyl triazine) and 2,4,6-tris [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: ethyl hexyl triazone) in the preparation is 0.05 to 4.00% by weight, based on the total weight of the preparation.
    [13]
    13. Preparation, process or use according to one of the preceding claims, characterized by the fact that the total concentration of salts of 2-phenylbenzimidazole-5sulfonic acid and 2-ethylhexyl-2-hydroxybenzoate (INCI: ethylhexyl salicylate) in the preparation is 0.05 to 5.00% by weight, based on the total weight of the preparation.
    [14]
    14. Preparation, process or use according to one of the preceding claims, characterized in that the preparation contains a combination of phenoxyethanol and acetate
    Petition 870180072198, of 17/08/2018, p. 29/31
    4/4 tocopheryl, respectively, tocopherol.
    [15]
    15. Preparation, process or use according to one of the preceding claims, characterized in that the preparation contains one or more of the perfumes hexyl salicylate, linalyl acetate, 2-isobutyl-4-hydroxy-4methyltetrahydropyran, adipic acid diester , methylheptenone, alpha-isomethionone, butylphenylmethylpropioal, coumarin, hexylcinnamal, limonene, linalool, diethyl succinate, hydroxy-isohexyl 3-cyclohexenecarboxaldehyde, diethyl succinate, menthyl-PCA and benzyl methyl alcohol, benzylate, benzylate, benzoate , benzyl cinnamate, benzyl salicylate, citronellol, eugenol, geraniol.
    [16]
    16. Preparation, process or use according to one of the preceding claims, characterized in that the preparation contains ethylhexylglycerin, propylene glycol, butylene glycol, 2-methylpropan-1,3-diol, 1,2-pentanediol, 1,2hexanediol , 1,2-octanodiol and / or 1,2-decanediol.
    [17]
    17. Preparation, process or use according to one of the preceding claims, characterized by the fact that the preparation does not contain any parabens, as well as any methylisothiazolinone, chloromethylisothiazolinone and DMDMhydantoin, therefore, it is free of these constituent substances.
    Petition 870180072198, of 17/08/2018, p. 30/31
    1/1
    类似技术:
    公开号 | 公开日 | 专利标题
    BR102018000894A2|2018-10-30|octocrylene-free sunscreen with polyglyceryl-10-stearate
    AU2020200941B9|2021-04-15|Octocrylene-free sunscreen composition with low stickiness
    ES2815452T3|2021-03-30|Use of diethylamino hydroxybenzoyl hexyl benzoate in cosmetic sunscreens
    ES2894740T3|2022-02-15|Sunscreen product with greatly reduced staining on textile materials by means of 4-|-4‘-methoxydibenzoylmethane
    ES2789324T3|2020-10-26|Sunscreen product with reduced textile staining by 4- | -4'-methoxydibenzoylmethane
    AU2016235018A1|2017-04-20|Sunscreen compositions with reduced textile staining as a result of Diethylamino Hydroxybenzoyl Hexyl Benzoate
    ES2759865T3|2020-05-12|Sunscreen with reduced staining on textiles reduced by bis-ethylhexyloxyphenol methoxyphenyl triazine
    ES2756528T3|2020-04-27|Sunscreen with intense reduction of the formation of stains on textile materials by bis-ethylhexyloxyphenol methoxyphenyl triazine
    BR102018005651A2|2018-10-30|sunscreen with triacontanila pvp
    BR112020018137A2|2020-12-22|COMPOSITION OF SUNSCREEN WITH REDUCED TREND TO STAIN TISSUES CONTAINING HYDROGENED VEGETABLE OIL AND A COMBINATION OF UVDEETHYLEXYL TRIAZONAE4- | -4? -METOXIDIBENZOILMETAN
    BR102016010930B1|2021-05-18|cosmetic preparation
    ES2859729T3|2021-10-04|Sunscreen product with polyglyceryl-10 stearate and polyglyceryl-2 caprate
    EP3600565B1|2021-09-22|Sunscreen containing polyglyceryl-10 stearate and linalool
    EP3600564B1|2021-09-22|Sunscreen containing polyglyceryl-10 stearate and citronellol
    BR112020018136A2|2020-12-22|COMPOSITION OF SUNSCREEN WITH REDUCED TREND TO STAIN TISSUES CONTAINING HYDROGENED VEGETABLE OIL AND BIS-ETHYL-HEXYLOXYphenolmethoxyphenyl TRIAZINE
    同族专利:
    公开号 | 公开日
    CN108392432A|2018-08-14|
    EP3351236A1|2018-07-25|
    EP3351236B1|2020-05-13|
    DE102017200723A1|2018-07-19|
    AU2018200385A1|2018-08-02|
    ES2810928T3|2021-03-09|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE102007024346A1|2007-05-22|2008-11-27|Beiersdorf Ag|Cosmetic formulation for protecting skin aging, particularly UV-induced skin aging, and for use in cosmetic sprays as sun protective agents, comprises dihydropyridine ethyloxysulfate ester salt and hydoxybenzoyl benzoic acid hexyl ester|
    DE102008021631A1|2008-04-25|2009-10-29|Beiersdorf Ag|Sunscreen filter combination with 2,4,6-tris- -1,3,5-triazine|
    DE102011077037A1|2011-06-07|2012-12-13|Beiersdorf Ag|Cosmetic or dermatological sunscreen formulation with improved water resistance|
    EP2717834A2|2011-06-08|2014-04-16|DSM IP Assets B.V.|Topical composition|
    DE102011088962A1|2011-12-19|2013-06-20|Beiersdorf Ag|Active ingredient combinations of one or more carboxylic acids, in particular hydroxycarboxylic acids, and one or more physiologically acceptable hydroxamic acid and cosmetic or dermatological preparations containing such active ingredient combinations|
    DE102013200819A1|2013-01-18|2014-07-24|Beiersdorf Ag|Active substance combination useful in a cosmetic- or dermatological formulation, comprises dehydroacetic acid and at least one polyol|
    DE102013213175A1|2013-07-04|2015-01-08|Beiersdorf Ag|Sunscreen with high triazine content|
    DE102013213170A1|2013-07-04|2015-01-08|Beiersdorf Ag|Octocrylene-free, odor-stable sunscreen|
    DE102013213174A1|2013-07-04|2015-01-08|Beiersdorf Ag|Octocrylene-free sunscreen|
    DE102014201541A1|2014-01-29|2015-07-30|Beiersdorf Ag|Octocrylene-free sunscreen with low tack|
    DE102014202956A1|2014-02-18|2015-08-20|Beiersdorf Ag|Cosmetic emulsifier combination|
    DE102014207602A1|2014-04-23|2015-10-29|Beiersdorf Ag|Emulsion base for sunscreen|
    DE102014216602A1|2014-08-21|2016-02-25|Beiersdorf Ag|Stable cosmetic preparation|
    DE102015212122A1|2015-06-25|2016-12-29|Beiersdorf Ag|Sprayable sunscreen with defined wax mixture|
    DE102015211790A1|2015-06-25|2016-12-29|Beiersdorf Ag|Ethanolic sunscreen with starting material for the formation of 4- -4'-methoxydibenzoylmethane|
    DE102015211793A1|2015-06-25|2016-12-29|Beiersdorf Ag|Alkanediol-containing sunscreen with starting material for the formation of 4- -4'-methoxydibenzoylmethan|
    DE102015211792A1|2015-06-25|2016-12-29|Beiersdorf Ag|Sunscreen with starting material for the formation of 4- -4'-methoxydibenzoylmethane|DE102017201235A1|2017-01-26|2018-07-26|Beiersdorf Ag|Use of dimethylaminohydroxybenzoylhexylbenzoate in cosmetic sunscreens|
    DE102017204794A1|2017-03-22|2018-09-27|Beiersdorf Ag|Sunscreen with triacontanyl PVP|
    DE102017204792A1|2017-03-22|2018-09-27|Beiersdorf Ag|Sunscreen with polyglyceryl-10 stearate and linalool|
    DE102017204793A1|2017-03-22|2018-09-27|Beiersdorf Ag|Sunscreen with polyglyceryl-10 stearate and polyclyceryl-2 caprate|
    DE102017204791A1|2017-03-22|2018-09-27|Beiersdorf Ag|Sunscreen with polyglyceryl-10 stearate and citronellol|
    DE102017213219A1|2017-08-01|2019-02-07|Beiersdorf Ag|Sunscreen with low eye irritation potential|
    CN113573690A|2019-03-15|2021-10-29|巴斯夫欧洲公司|Effective sunscreen composition with diethylamino hydroxybenzoyl hexyl benzoate and butyl methoxy dibenzoyl methane and without octocrylene|
    KR20210138666A|2019-03-15|2021-11-19|바스프 에스이|Efficient sunscreen composition with diethylamino hydroxybenzoyl hexyl benzoate and butyl methoxydibenzoylmethane|
    KR20210138667A|2019-03-15|2021-11-19|바스프 에스이|Efficient sunscreen composition with diethylamino hydroxybenzoyl hexyl benzoate and water soluble UVA filter|
    EP3937898A1|2019-03-15|2022-01-19|Basf Se|Efficient sunscreen compositions with diethylamino hydroxybenzoyl hexyl benzoate and organic particulate uv filter|
    WO2020187766A1|2019-03-15|2020-09-24|Basf Se|Efficient sunscreen compositions with diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoylmethane and organic particulate uv filter|
    FR3095757B1|2019-05-10|2021-05-21|Fabre Pierre Dermo Cosmetique|PHOTOPROTECTOR SYSTEM CONSISTING OF 4 SOLAR FILTERS|
    WO2021102874A1|2019-11-29|2021-06-03|Beiersdorf Daily ChemicalCo., Ltd.|An oil-in-water sunscreen composition|
    DE102020201799A1|2020-02-13|2021-08-19|Beiersdorf Aktiengesellschaft|Polyacrylate-free cosmetic preparation|
    LU101670B1|2020-03-09|2021-09-10|Soc De Recherche Cosmetique Sarl|Sun protection topical composition|
    法律状态:
    2018-10-30| B03A| Publication of an application: publication of a patent application or of a certificate of addition of invention|
    优先权:
    申请号 | 申请日 | 专利标题
    DE102017200723.0A|DE102017200723A1|2017-01-18|2017-01-18|Octocrylene-free sunscreen with polyglyceryl-10 stearate|
    [返回顶部]